Lieve jongens, stoere meiden. Het matrozepakje in genderperspectief, 1770-2000

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Conventional pharmacologic treatments for major depressive disorder (MDD) generally take several weeks to several months to have a clinically meaningful effect. This time lag to response constitutes a major burden for patients and contributes to increased morbidity and mortality. Two published studies in patients with MDD have now provided evidence for rapid and robust antidepressant efficacy o...

De zwaargewonden eerst? Het Nederlandsche Roode Kruis en het vraagstuk van oorlog in vrede 1867–1945

emotional and intellectual rationales for the movement. At the same time he explores in meticulous detail the complicated practical politics involved. The heart of the story lies in the irony of the movement's survival, the success of the philanthropic effort to "civilize war" being met only through accommodation to, and then generous assistance of, the militaristic interests of individual nati...

The making of man-midwifery: childbirth in England, 1660–1770

history of social policy, for it is all too easy to assume that identification and classification somehow make it easier to "target" areas of special need. What the municipal authorities seem to have taken for granted is the interpenetration of problems such as poverty, health, training and homelessness, acknowledging thereby the social basis of many medical problems and the need to encourage e...

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prio...